S-equol is backed by decades of research†

HCP Research History

1984

Therapeutic Interest in S-equol

First demonstration that S-equol can be used to treat estrogen-mediated conditions.
Setchell KD, et al. Am J Clin Nutr. 1984;40:569–78.

1985

Soy Protective for Health

WHO CARDIAC Study explores the relationship between diet and longevity–focusing particularly on soybeans and women’s health.

1995

Soy Reduces Menopause Symptoms

Post–menopausal women who consumed soy flour experienced fewer menopause symptoms compared to baseline.
Murkies AL, et al. Maturitas. 1995;21(3):189-95.

2002

Natural Fermentation

Lactic acid bacteria that produces S-equol identified in fermented soybean germ.

2005

How S-equol is Metabolized

Review of how daidzein, a soy isoflavone, is metabolized to equol.
Atkinson C, et al. Experimental biology and medicine. 2005;230(3):155-70.

2007

S-equol Correlated with Reduced Symptoms

Correlational analysis suggesting more equol production linked to reduced symptoms.
Uchiyama S, et al. J Jpn Menopause Soc. 2007; 15:28-37.

2009

S-equol Improves Mood

Women taking S-equol improved on 4 of the 6 POMS (profile of moods) categories compared to placebo.
Ishiwata N, et al. Menopause. 2009; 16:141-148.
STUDY DESIGN
A 12-Week randomized, double-blind, placebo-controlled trial with 134 women, ranging peri- to post-menopausal, aged 40–59 years.
X

2012

S-equol Reduces Vasomotor Symptoms

S-equol reduced hot flashes and shoulder and neck stiffness compared to placebo.
Aso T, et al. J of Women's Health. 2012;21(1):92-100.
STUDY DESIGN
A 12-Week, double-blind placebo-controlled trial of 160 post-menopausal women who experienced at least one hot flash a day.
X
 
S-equol significantly reduced hot flash frequency, compared to baseline. Additionally, S-equol was more effective for relieving muscle and joint pain than placebo (soy isoflavone).
Jenks B, et al. J of Women's Health. 2012; 21(6):674-82.
STUDY DESIGN
An 8-Week randomized, double-blind trial with 102 post-menopausal women, aged 45–65 years, who experienced approximately 5 hot flashes/day.
X

2014

Worldwide Launch

EQUELLE first launches in Japan.

2018

United States Launch

EQUELLE is now widely available in the United States.
HCP Research History

1984

Therapeutic Interest in S-equol

First demonstration that S-equol can be used to treat estrogen-mediated conditions.
Setchell KD, et al. Am J Clin Nutr. 1984;40:569–78.

1985

Soy Protective for Health

WHO CARDIAC Study explores the relationship between diet and longevity–focusing particularly on soybeans and women’s health.

1995

Soy Reduces Menopause Symptoms

Post–menopausal women who consumed soy flour experienced fewer menopause symptoms compared to baseline.
Murkies AL, et al. Maturitas. 1995;21(3):189-95.

2002

Natural Fermentation

Lactic acid bacteria that produces S-equol identified in fermented soybean germ.

2005

How S-equol is Metabolized

Review of how daidzein, a soy isoflavone, is metabolized to equol.
Atkinson C, et al. Experimental biology and medicine. 2005;230(3):155-70.

2007

S-equol Correlated with Reduced Symptoms

Correlational analysis suggesting more equol production linked to reduced symptoms.
Uchiyama S, et al. J Jpn Menopause Soc. 2007; 15:28-37.

2009

S-equol Improves Mood

Women taking S-equol improved on 4 of the 6 POMS (profile of moods) categories compared to placebo.
Ishiwata N, et al. Menopause. 2009; 16:141-148.
STUDY DESIGN
A 12-Week randomized, double-blind, placebo-controlled trial with 134 women, ranging peri- to post-menopausal, aged 40–59 years.
X

2012

S-equol Reduces Vasomotor Symptoms

S-equol reduced hot flashes and shoulder and neck stiffness compared to placebo.
Aso T, et al. J of Women's Health. 2012;21(1):92-100.
STUDY DESIGN
A 12-Week, double-blind placebo-controlled trial of 160 post-menopausal women who experienced at least one hot flash a day.
X
 
S-equol significantly reduced hot flash frequency, compared to baseline. Additionally, S-equol was more effective for relieving muscle and joint pain than placebo (soy isoflavone).
Jenks B, et al. J of Women's Health. 2012; 21(6):674-82.
STUDY DESIGN
An 8-Week randomized, double-blind trial with 102 post-menopausal women, aged 45–65 years, who experienced approximately 5 hot flashes/day.
X

2014

Worldwide Launch

EQUELLE first launches in Japan.

2018

United States Launch

EQUELLE is now widely available in the United States.

EQUELLE is well researched across 3 clinical trials with over 350 patients

EQUELLE showed a significant reduction in hot flash frequency, and it was also shown to support sleep quality and vaginal health as well as alleviate mood swings1-3†
see CLINICALLY VALIDATED data

EQUELLE uses a nonhormonal compound to relieve menopause symptoms*†

HCP Research History
Naturally derived‡ S-equol binds to estrogen receptors to mimic some but not all of the effects of estrogen by preferentially binding to ER-ß over ER-α without affecting sex and thyroid hormone concentrations.4,5
S-equol molecule
Explore the mechanism of action
Explore the moa

Connect with EQUELLE for practice materials including:

Patient education icon
Patient educational materials
Savings icon
Exclusive savings for your patients
Sample icon
7-day samples of equelle
Sample icon
Practice support and additional offerings from Nature Made
Request more information
References: 1. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health. 2012;21(6):674-682. 2. Aso T, Uchiyama S, Matsumura Y, et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health. 2012;21(1):92-100. 3. Data on File. 1811 Study Report; Pharmavite LLC. 4. Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial. Menopause. 2011;18(5):563-574. 5. Muthyala RS, Ju YH, Sheng S, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem. 2004;12(6):1559-1567.